At age 19, Alexander Wang moved to New York City to attend Parsons School of Design. In 2005, after two years at Parsons, he decided to pursue the launch of his own fashion label, which predominantly began with a knitwear collection. In Fall 2007, Wang presented a complete women’s ready-to-wear collection on the New York catwalk for the first time, to critical acclaim. He won the CFDA/Vogue Fashion Fund in 2008, an honor accompanied by a $20,000 award to expand one's business. The same year, he launched his first handbag collection. In 2009, women’s T by Alexander Wang was launched, followed by Men’s T a year later. In 2009 he was recognized by his peers, when he was announced as winner of the CFDA’s Swarovski Womenswear Designer of the Year Award. Also in 2009, Wang was the recipient of the Swiss Textiles Award. His lines are now stocked globally in more than 700 stores and other venues; including, luxury department stores, such as Bloomingdale's, Barneys New York, Neiman Marcus, Bergdorf Goodman, Dover Street Market, Browns and Net-a-Porter.
Wang is known for his urban designs. After designing a Fall 2008 collection using black as predominant color, he designed his Spring 2009 collection using bright colors, as orange, dusty purple, aqua and hot pink. In the meantime he has reverted to use mainly black fabrics, and is often praised for exhibiting outstanding tailoring skills. On July 31, 2015, it was announced that Alexander Wang would leave Balenciaga.
On April 13, 2014 it was announced that Alexander Wang would be the next designer to create a collection for Swedish based fashion retailer H&M. The collection was available at H&M stores and online November 6, 2014. The collection with H&M included pieces for both men and women, as well as a selection of his famed accessories. The news was unveiled via the designer’s personal Instagram page.
In 2016, he has been awarded $90 million in damages after successfully suing over 45 defendants operating 459 websites that sold counterfeit goods bearing its name. He hosts a New York Fashion Week show.